Lizzo reacts to South Park joke about her in episode about Ozempic

Lizzo was namechecked in South Park episode The End of Obesity. Before watching the clip, she said being referenced in the cartoon was her "worst fear" – but her take on the show's creators changed by the end of the video.

Lizzo says being referenced in a South Park episode is her "worst fear" – and shared her reaction to the joke in real time on social media. 

The popstar was namechecked in the latest episode of the long-running cartoon, The End of Obesity, which parodies the popularity of weight-loss drugs such as Ozempic and Mounjaro.

Lizzo shared a clip from the show alongside her reaction to the scene – opening the video by saying: "I'm so scared."

The clip features a conversation between Sharon and Sheila, the mothers of Stan and Kyle.

Sharon says her doctor wouldn't prescribe her any weight-loss injections because she doesn't have diabetes, but says "there's a whole new obesity drug for those of us who can't afford Ozempic and Mounjaro".

"I controlled all my cravings to be thinner with 'Lizzo'," she says – prompting the singer to clap her hand over her mouth.

The clip then goes into a fake advert for "Lizzo", which says the drug makes users "feel good about [their] weight," claiming that 70% of those who took it "no longer cared how much they weighed".

"Lizzo helps you eat everything you want and keep physical activity to a minimum," the voiceover says.

"Some patients report constipation while listening to Lizzo. Stop listening to Lizzo if you experience suicidal thoughts."

At the end of the ad, the voiceover asks: "Are you living with concerns of obesity?"

Sharon turns to the camera and says: "Ask about the power of not giving a f*** – with Lizzo" – as the singer looks on wide-eyed and open-mouthed.

"That's crazy!", Lizzo says as the clip finishes.

"I really showed the world how to love yourself and not give a f***, to the point where these men [South Park creators Trey Parker and Matt Stone] in Colorado know who the f*** I am, and put it on their cartoon that's been around for 25 years," she says.

"I'm really that bitch, and I show you how to not give a f*** and I'll keep showing you how to not give a f***."

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Lizzo is known for championing body positivity and is no stranger to fat shaming.

She has been credited with changing the narrative around plus-size women, calling out sizeist behaviour and refusing to conform to industry stereotypes.

However, last year the singer faced claims she is guilty of weight shaming and sexual harassment – allegations she denies – with three of her former singers bringing a lawsuit against her.